Sepsis
(Last Updated - 8/9/2007)
-Definition:
-SIRS plus infection
-Severe Sepsis:
-Sepsis plus at least 1 of the following:
1) Mottled skin
2) Capillary refilling >= 3 sec
3) UOP < 0.5 mL/kg x1 hour or requiring CRRT
4) Lactate > 2 mmol/L
5) Abrupt mental status changes
6) Abnormal EEG
7) Plat's < 100,000
8) DIC
9) Acute lung injury (ALI) or ARDS
10) Cardiac dysfunction --> by EKG or direct measurement of cardiac index (CI)
-Septic Shock:
-Severe sepsis plus 1 or both of the following:
1) MAP < 60 mmHg (or < 80 mmHg if baseline HTN) despite adequate IVF resuscitation (PCWP 12-20)
2) Maintaining MAP > 60 mmHg (or < 80 mmHg if baseline HTN) requires pressors
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